The Nrf2ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease
Joint Authors
Genc, Sermin
Civi Bayin, Ezgi
Tufekci, Kemal Ugur
Genc, Kursad
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases as strict regulation of integrated mitochondrial functions is essential for neuronal signaling, plasticity, and transmitter release.
Many lines of evidence suggest that mitochondrial dysfunction plays a central role in the pathogenesis of Parkinson's disease (PD).
Several PD-associated genes interface with mitochondrial dynamics regulating the structure and function of the mitochondrial network.
Mitochondrial dysfunction can induce neuron death through a plethora of mechanisms.
Both mitochondrial dysfunction and neuroinflammation, a common denominator of PD, lead to an increased production of reactive oxygen species, which are detrimental to neurons.
The transcription factor nuclear factor E2-related factor 2 (Nrf2, NFE2L2) is an emerging target to counteract mitochondrial dysfunction and its consequences in PD.
Nrf2 activates the antioxidant response element (ARE) pathway, including a battery of cytoprotective genes such as antioxidants and anti-inflammatory genes and several transcription factors involved in mitochondrial biogenesis.
Here, the current knowledge about the role of mitochondrial dysfunction in PD, Nrf2/ARE stress-response mechanisms, and the evidence for specific links between this pathway and PD are summarized.
The neuroprotection of nigral dopaminergic neurons by the activation of Nrf2 through several inducers in PD is also emphasized as a promising therapeutic approach.
American Psychological Association (APA)
Tufekci, Kemal Ugur& Civi Bayin, Ezgi& Genc, Sermin& Genc, Kursad. 2011. The Nrf2ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease. Parkinson’s Disease،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-991047
Modern Language Association (MLA)
Tufekci, Kemal Ugur…[et al.]. The Nrf2ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease. Parkinson’s Disease No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-991047
American Medical Association (AMA)
Tufekci, Kemal Ugur& Civi Bayin, Ezgi& Genc, Sermin& Genc, Kursad. The Nrf2ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease. Parkinson’s Disease. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-991047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991047