Sleep Duration and “on” Time during Different Periods of the Day and Night in Patients with Advanced Parkinson's Disease Receiving Adjunctive Ropinirole Prolonged Release
Joint Authors
Martinez-Martin, Pablo
Cooper, James
Rolfe, Katie
Reichmann, Heinz
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Patients undergoing long-term therapy for PD often experience motor fluctuations and nocturnal disturbances.
In a post-hoc analysis, we explored effects of ropinirole prolonged release on sleep, night-time awakenings, and “on” time over 24 hours.
Patients with advanced PD suboptimally controlled with L-dopa were randomized to adjunctive ropinirole prolonged release (2–24 mg/day) or placebo for 24 weeks.
Awake/asleep and, if awake, “on”/“off” status was recorded via diary cards.
At week 24 last observation carried forward, changes in nighttime or daytime sleep duration were not significantly different between treatments.
Of patients with baseline awakenings, a significantly higher proportion in the ropinirole prolonged release group had a reduction in awakenings versus placebo.
Patients receiving ropinirole prolonged release had a significantly greater increase in amount/percentage of awake time “on”/“on” without troublesome dyskinesia during all periods assessed (including night-time and early morning), versus placebo, and higher odds for being “on” on waking.
Adjunctive once-daily ropinirole prolonged release may help provide 24-hour symptom control in patients with advanced PD not optimally controlled with L-dopa.
American Psychological Association (APA)
Reichmann, Heinz& Cooper, James& Rolfe, Katie& Martinez-Martin, Pablo. 2011. Sleep Duration and “on” Time during Different Periods of the Day and Night in Patients with Advanced Parkinson's Disease Receiving Adjunctive Ropinirole Prolonged Release. Parkinson’s Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-991051
Modern Language Association (MLA)
Reichmann, Heinz…[et al.]. Sleep Duration and “on” Time during Different Periods of the Day and Night in Patients with Advanced Parkinson's Disease Receiving Adjunctive Ropinirole Prolonged Release. Parkinson’s Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-991051
American Medical Association (AMA)
Reichmann, Heinz& Cooper, James& Rolfe, Katie& Martinez-Martin, Pablo. Sleep Duration and “on” Time during Different Periods of the Day and Night in Patients with Advanced Parkinson's Disease Receiving Adjunctive Ropinirole Prolonged Release. Parkinson’s Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-991051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991051