Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Voice Intensity

Abstract EN

Deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with Parkinson's disease (PD) affects speech inconsistently.

Recently, stimulation of the caudal zona incerta (cZi-DBS) has shown superior motor outcomes for PD patients, but effects on speech have not been systematically investigated.

The aim of this study was to compare the effects of cZi-DBS and STN-DBS on voice intensity in PD patients.

Mean intensity during reading and intensity decay during rapid syllable repetition were measured for STN-DBS and cZi-DBS patients (eight patients per group), before- and 12 months after-surgery on- and off-stimulation.

For mean intensity, there were small significant differences on- versus off-stimulation in each group: 74.2 (2.0) dB contra 72.1 (2.2) dB (P=.002) for STN-DBS, and 71.6 (4.1) dB contra 72.8 (3.4) dB (P=.03) for cZi-DBS, with significant interaction (P<.001).

Intensity decay showed no significant changes.

The subtle differences found for mean intensity suggest that STN-DBS and cZi-DBS may influence voice intensity differently.