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Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy?
Joint Authors
Carta, Anna Rosa
Carboni, Ezio
Pisanu, Augusta
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor (PPAR)-γ agonists commonly used as insulin-sensitizing drugs for the treatment of type 2 diabetes.
In the last decade, PPAR-γ agonists have received increasing attention for their neuroprotective properties displayed in a variety of neurodegenerative diseases, including Parkinson's disease (PD), likely related to the anti-infammatory activity of these compounds.
Recent studies indicate that neuroinflammation, specifically reactive microglia, plays important roles in PD pathogenesis.
Moreover, after the discovery of infiltrating activated Limphocytes in the substantia nigra (SN) of PD patients, most recent research supports a role of immune-mediated mechanisms in the pathological process leading to chronic neuroinflammation and dopaminergic degeneration.
PPAR-γ are highly expressed in cells of both central and peripheral immune systems, playing a pivotal role in microglial activation as well as in monocytes and T cells differentiation, in which they act as key regulators of immune responses.
Here, we review preclinical evidences of PPAR-γ-induced neuroprotection in experimental PD models and highlight relative anti-inflammatory mechanisms involving either central or peripheral immunomodulatory activity.
Specific targeting of immune functions contributing to neuroinflammation either directly (central) or indirectly (peripheral) may represent a novel therapeutic approach for disease modifying therapies in PD.
American Psychological Association (APA)
Carta, Anna Rosa& Pisanu, Augusta& Carboni, Ezio. 2011. Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy?. Parkinson’s Disease،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-991088
Modern Language Association (MLA)
Carta, Anna Rosa…[et al.]. Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy?. Parkinson’s Disease No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-991088
American Medical Association (AMA)
Carta, Anna Rosa& Pisanu, Augusta& Carboni, Ezio. Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy?. Parkinson’s Disease. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-991088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991088