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Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD
Joint Authors
de Oliveira, Catarina Resende
Cardoso, Sandra M.
Arduíno, Daniela M.
Silva, D. F. F.
Esteves, A. Raquel
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-03
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
While the etiology of Parkinson's disease remains largely elusive, there is accumulating evidence suggesting that mitochondrial dysfunction occurs prior to the onset of symptoms in Parkinson's disease.
Mitochondria are remarkably primed to play a vital role in neuronal cell survival since they are key regulators of energy metabolism (as ATP producers), of intracellular calcium homeostasis, of NAD+/NADH ratio, and of endogenous reactive oxygen species production and programmed cell death.
In this paper, we focus on mitochondrial dysfunction-mediated alpha-synuclein aggregation.
We highlight some of the findings that provide proof of evidence for a mitochondrial metabolism control in Parkinson's disease, namely, mitochondrial regulation of microtubule-dependent cellular traffic and autophagic lysosomal pathway.
The knowledge that microtubule alterations may lead to autophagic deficiency and may compromise the cellular degradation mechanisms that culminate in the progressive accumulation of aberrant protein aggregates shields new insights to the way we address Parkinson's disease.
In line with this knowledge, an innovative window for new therapeutic strategies aimed to restore microtubule network may be unlocked.
American Psychological Association (APA)
Esteves, A. Raquel& Arduíno, Daniela M.& Silva, D. F. F.& de Oliveira, Catarina Resende& Cardoso, Sandra M.. 2011. Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. Parkinson’s Disease،Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-991090
Modern Language Association (MLA)
Esteves, A. Raquel…[et al.]. Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. Parkinson’s Disease No. 2011 (2011), pp.1-20.
https://search.emarefa.net/detail/BIM-991090
American Medical Association (AMA)
Esteves, A. Raquel& Arduíno, Daniela M.& Silva, D. F. F.& de Oliveira, Catarina Resende& Cardoso, Sandra M.. Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. Parkinson’s Disease. 2011. Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-991090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991090