Mitochondrial FusionFission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty

Joint Authors

Cardoso, Sandra M.
Arduíno, Daniela M.
Esteves, A. Raquel

Source

Parkinson’s Disease

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-01-13

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Diseases
Medicine

Abstract EN

Understanding the molecular basis of Parkinson's disease (PD) has proven to be a major challenge in the field of neurodegenerative diseases.

Although several hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of PD, a growing body of evidence has highlighted the role of mitochondrial dysfunction and the disruption of the mechanisms of mitochondrial dynamics in PD and other parkinsonian disorders.

In this paper, we comment on the recent advances in how changes in the mitochondrial function and mitochondrial dynamics (fusion/fission, transport, and clearance) contribute to neurodegeneration, specifically focusing on PD.

We also evaluate the current controversies in those issues and discuss the role of fusion/fission dynamics in the mitochondrial lifecycle and maintenance.

We propose that cellular demise and neurodegeneration in PD are due to the interplay between mitochondrial dysfunction, mitochondrial trafficking disruption, and impaired autophagic clearance.

American Psychological Association (APA)

Arduíno, Daniela M.& Esteves, A. Raquel& Cardoso, Sandra M.. 2011. Mitochondrial FusionFission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty. Parkinson’s Disease،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-991110

Modern Language Association (MLA)

Arduíno, Daniela M.…[et al.]. Mitochondrial FusionFission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty. Parkinson’s Disease No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-991110

American Medical Association (AMA)

Arduíno, Daniela M.& Esteves, A. Raquel& Cardoso, Sandra M.. Mitochondrial FusionFission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty. Parkinson’s Disease. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-991110

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-991110