Bladder, Bowel, and Sexual Dysfunction in Parkinson's Disease
Joint Authors
Uchiyama, Tomoyuki
Yamanishi, Tomonori
Yamamoto, Tatsuya
Tateno, Fuyuki
Kishi, Masahiko
Ogawa, Emina
Sakakibara, Ryuji
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-12
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Bladder dysfunction (urinary urgency/frequency), bowel dysfunction (constipation), and sexual dysfunction (erectile dysfunction) (also called “pelvic organ” dysfunctions) are common nonmotor disorders in Parkinson's disease (PD).
In contrast to motor disorders, pelvic organ autonomic dysfunctions are often nonresponsive to levodopa treatment.
The brain pathology causing the bladder dysfunction (appearance of overactivity) involves an altered dopamine-basal ganglia circuit, which normally suppresses the micturition reflex.
By contrast, peripheral myenteric pathology causing slowed colonic transit (loss of rectal contractions) and central pathology causing weak strain and paradoxical anal sphincter contraction on defecation (PSD, also called as anismus) are responsible for the bowel dysfunction.
In addition, hypothalamic dysfunction is mostly responsible for the sexual dysfunction (decrease in libido and erection) in PD, via altered dopamine-oxytocin pathways, which normally promote libido and erection.
The pathophysiology of the pelvic organ dysfunction in PD differs from that in multiple system atrophy; therefore, it might aid in differential diagnosis.
Anticholinergic agents are used to treat bladder dysfunction in PD, although these drugs should be used with caution particularly in elderly patients who have cognitive decline.
Dietary fibers, laxatives, and “prokinetic” drugs such as serotonergic agonists are used to treat bowel dysfunction in PD.
Phosphodiesterase inhibitors are used to treat sexual dysfunction in PD.
These treatments might be beneficial in maximizing the patients' quality of life.
American Psychological Association (APA)
Sakakibara, Ryuji& Kishi, Masahiko& Ogawa, Emina& Tateno, Fuyuki& Uchiyama, Tomoyuki& Yamamoto, Tatsuya…[et al.]. 2011. Bladder, Bowel, and Sexual Dysfunction in Parkinson's Disease. Parkinson’s Disease،Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-991123
Modern Language Association (MLA)
Sakakibara, Ryuji…[et al.]. Bladder, Bowel, and Sexual Dysfunction in Parkinson's Disease. Parkinson’s Disease No. 2011 (2011), pp.1-21.
https://search.emarefa.net/detail/BIM-991123
American Medical Association (AMA)
Sakakibara, Ryuji& Kishi, Masahiko& Ogawa, Emina& Tateno, Fuyuki& Uchiyama, Tomoyuki& Yamamoto, Tatsuya…[et al.]. Bladder, Bowel, and Sexual Dysfunction in Parkinson's Disease. Parkinson’s Disease. 2011. Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-991123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991123