The Degenerating Substantia Nigra as a Susceptible Region for Gene Transfer-Mediated Inflammation
Joint Authors
Radice, Pablo
Roca, Valeria
Murta, Verónica
Casabona, Juan Cruz
Juan Pitossi, Fernando
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Parkinson's disease (PD) is characterized by the progressive degeneration of neurons in the substantia nigra pars compacta (SN).
The naïve SN is highly susceptible to inflammation.
In addition, microglial activation in the degenerating SN displays distinct characteristics that increase the reactivity of the region towards inflammatory stimuli.
On the other hand, gene therapy for PD has recently move forward into clinical settings, with PD being the neurodegenerative disorder with the highest number of Phase I/II gene therapy clinical trials approved and completed.
These clinical trials are not targeting the SN, but this region is a certain candidate for future gene therapy interventions.
Here, the unique immune-related properties of the degenerating SN in the context of a putative gene therapy intervention are reviewed.
Several variables affecting the host response to gene delivery such as vector type and dosage, age and stage of disease of patients, and method of gene delivery and transgene used are discussed.
Finally, approaches to diminish the risk of immune-mediated toxicity by gene transfer in the SN are presented.
American Psychological Association (APA)
Roca, Valeria& Casabona, Juan Cruz& Radice, Pablo& Murta, Verónica& Juan Pitossi, Fernando. 2011. The Degenerating Substantia Nigra as a Susceptible Region for Gene Transfer-Mediated Inflammation. Parkinson’s Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-991124
Modern Language Association (MLA)
Roca, Valeria…[et al.]. The Degenerating Substantia Nigra as a Susceptible Region for Gene Transfer-Mediated Inflammation. Parkinson’s Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-991124
American Medical Association (AMA)
Roca, Valeria& Casabona, Juan Cruz& Radice, Pablo& Murta, Verónica& Juan Pitossi, Fernando. The Degenerating Substantia Nigra as a Susceptible Region for Gene Transfer-Mediated Inflammation. Parkinson’s Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-991124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991124