Toxin-Induced and Genetic Animal Models of Parkinson's Disease
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Parkinson's disease (PD) is a common progressive neurodegenerative disorder.
The major pathological hallmarks of PD are the selective loss of nigrostriatal dopaminergic neurons and the presence of intraneuronal aggregates termed Lewy bodies (LBs), but the pathophysiological mechanisms are not fully understood.
Epidemiologically, environmental neurotoxins such as pesticides are promising candidates for causative factors of PD.
Oxidative stress and mitochondrial dysfunction induced by these toxins could contribute to the progression of PD.
While most cases of PD are sporadic, specific mutations in genes that cause familial forms of PD have led to provide new insights into its pathogenesis.
This paper focuses on animal models of both toxin-induced and genetically determined PD that have provided significant insight for understanding this disease.
We also discuss the validity, benefits, and limitations of representative models.
American Psychological Association (APA)
Hisahara, Shin& Shimohama, Shun. 2010. Toxin-Induced and Genetic Animal Models of Parkinson's Disease. Parkinson’s Disease،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-991127
Modern Language Association (MLA)
Hisahara, Shin& Shimohama, Shun. Toxin-Induced and Genetic Animal Models of Parkinson's Disease. Parkinson’s Disease No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-991127
American Medical Association (AMA)
Hisahara, Shin& Shimohama, Shun. Toxin-Induced and Genetic Animal Models of Parkinson's Disease. Parkinson’s Disease. 2010. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-991127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991127