Tumor Vessel Development and Expansion in Ewing's Sarcoma: A Review of the Vasculogenesis Process and Clinical Trials with Vascular-Targeting Agents
Joint Authors
Kleinerman, Eugenie S.
Stewart, Keri S.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Ewing's sarcoma accounts for a disproportionately high portion of the overall pediatric mortality rate compared to its rare incidence in the pediatric population.
Little progress has been made since the introduction of traditional chemotherapies, and understanding the biology of the tumor is critical for developing new therapies.
Ewing's sarcomas rely on a functional vascular supply, which is formed by a combination of angiogenesis and vasculogenesis.
Recent insights into the molecular regulation of bone marrow (BM) cell participation in vascular development have identified VEGF, SDF-1α, and DLL4 as critical players in the vasculogenesis process.
Clinical trials using vascular targeting agents, specifically targeting VEGF or DLL4, are underway.
American Psychological Association (APA)
Stewart, Keri S.& Kleinerman, Eugenie S.. 2011. Tumor Vessel Development and Expansion in Ewing's Sarcoma: A Review of the Vasculogenesis Process and Clinical Trials with Vascular-Targeting Agents. Complexity،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-991152
Modern Language Association (MLA)
Stewart, Keri S.& Kleinerman, Eugenie S.. Tumor Vessel Development and Expansion in Ewing's Sarcoma: A Review of the Vasculogenesis Process and Clinical Trials with Vascular-Targeting Agents. Complexity No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-991152
American Medical Association (AMA)
Stewart, Keri S.& Kleinerman, Eugenie S.. Tumor Vessel Development and Expansion in Ewing's Sarcoma: A Review of the Vasculogenesis Process and Clinical Trials with Vascular-Targeting Agents. Complexity. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-991152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991152