Copy Number Alterations and Methylation in Ewing's Sarcoma
Joint Authors
Jahromi, Mona S.
Jones, Kevin B.
Schiffman, Joshua D.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ewing's sarcoma is the second most common bone malignancy affecting children and young adults.
The prognosis is especially poor in metastatic or relapsed disease.
The cell of origin remains elusive, but the EWS-FLI1 fusion oncoprotein is present in the majority of cases.
The understanding of the molecular basis of Ewing's sarcoma continues to progress slowly.
EWS-FLI1 affects gene expression, but other factors must also be at work such as mutations, gene copy number alterations, and promoter methylation.
This paper explores in depth two molecular aspects of Ewing's sarcoma: copy number alterations (CNAs) and methylation.
While CNAs consistently have been reported in Ewing's sarcoma, their clinical significance has been variable, most likely due to small sample size and tumor heterogeneity.
Methylation is thought to be important in oncogenesis and balanced karyotype cancers such as Ewing's, yet it has received only minimal attention in prior studies.
Future CNA and methylation studies will help to understand the molecular basis of this disease.
American Psychological Association (APA)
Jahromi, Mona S.& Jones, Kevin B.& Schiffman, Joshua D.. 2011. Copy Number Alterations and Methylation in Ewing's Sarcoma. Complexity،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-991167
Modern Language Association (MLA)
Jahromi, Mona S.…[et al.]. Copy Number Alterations and Methylation in Ewing's Sarcoma. Complexity No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-991167
American Medical Association (AMA)
Jahromi, Mona S.& Jones, Kevin B.& Schiffman, Joshua D.. Copy Number Alterations and Methylation in Ewing's Sarcoma. Complexity. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-991167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991167