miRNA Profiling: How to Bypass the Current Difficulties in the Diagnosis and Treatment of Sarcomas
Joint Authors
Alberti, Laurent
Pissaloux, Daniel
Besse, Anthony
Duc, Adeline
Blay, Jean-Yves
Gougelet, Angélique
Ranchere-Vince, Dominique
Decouvelaere, Anne-Valérie
Perez, Jennifer
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Sarcomas are divided into a group with specific alterations and a second presenting a complex karyotype, sometimes difficult to diagnose or with few therapeutic options available.
We assessed if miRNA profiling by TaqMan low density arrays could predict the response of undifferentiated rhabdomyosarcoma (RMS) and osteosarcoma to treatment.
We showed that miRNA signatures in response to a therapeutic agent (chemotherapy or the mTOR inhibitor RAD-001) were cell and drug specific on cell lines and a rat osteosarcoma model.
This miRNA signature was related to cell or tumour sensitivity to this treatment and might be not due to chromosomal aberrations, as revealed by a CGH array analysis of rat tumours.
Strikingly, miRNA profiling gave promising results for patient rhabdomyosarcoma, discriminating all types of RMS: (Pax+) or undifferentiated alveolar RMS as well as embryonal RMS.
As highlighted by these results, miRNA profiling emerges as a potent molecular diagnostic tool for complex karyotype sarcomas.
American Psychological Association (APA)
Gougelet, Angélique& Perez, Jennifer& Pissaloux, Daniel& Besse, Anthony& Duc, Adeline& Decouvelaere, Anne-Valérie…[et al.]. 2011. miRNA Profiling: How to Bypass the Current Difficulties in the Diagnosis and Treatment of Sarcomas. Complexity،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-991184
Modern Language Association (MLA)
Gougelet, Angélique…[et al.]. miRNA Profiling: How to Bypass the Current Difficulties in the Diagnosis and Treatment of Sarcomas. Complexity No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-991184
American Medical Association (AMA)
Gougelet, Angélique& Perez, Jennifer& Pissaloux, Daniel& Besse, Anthony& Duc, Adeline& Decouvelaere, Anne-Valérie…[et al.]. miRNA Profiling: How to Bypass the Current Difficulties in the Diagnosis and Treatment of Sarcomas. Complexity. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-991184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991184