Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Miceas an Animal Model of Spontaneous Uterine Leiomyosarcoma
Joint Authors
Shiozawa, Tanri
Sano, Kenji
Kanai, Yae
Hayashi, Takuma
Hiraoka, Nobuyoshi
Tonegawa, Susumu
Konishi, Ikuo
Horiuchi, Akiko
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix.
The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known.
Importantly, a diagnostic-biomarker which distinguishes malignant LMS from benign tumor leiomyoma (LMA) is yet to be established.
Accordingly, it is necessary to analyze risk factors associated with uterine LMS, in order to establish a treatment method.
LMP2-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age.
We found LMP2 expression to be absent in human LMS, but present in human LMA.
Therefore, defective LMP2 expression may be one of the risk factors for LMS.
LMP2 is a potential diagnostic-biomarker for uterine LMS, and may be targeted-molecule for a new therapeutic approach.
American Psychological Association (APA)
Hayashi, Takuma& Horiuchi, Akiko& Sano, Kenji& Hiraoka, Nobuyoshi& Kanai, Yae& Shiozawa, Tanri…[et al.]. 2011. Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Miceas an Animal Model of Spontaneous Uterine Leiomyosarcoma. Complexity،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-991188
Modern Language Association (MLA)
Hayashi, Takuma…[et al.]. Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Miceas an Animal Model of Spontaneous Uterine Leiomyosarcoma. Complexity No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-991188
American Medical Association (AMA)
Hayashi, Takuma& Horiuchi, Akiko& Sano, Kenji& Hiraoka, Nobuyoshi& Kanai, Yae& Shiozawa, Tanri…[et al.]. Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Miceas an Animal Model of Spontaneous Uterine Leiomyosarcoma. Complexity. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-991188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991188