The Role of Chemokine Receptor CXCR4 in the Biologic Behavior of Human Soft Tissue Sarcoma
Joint Authors
Li, Benjamin D. L.
Chu, Quyen D.
Kim, Roger H.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The molecular basis of sarcoma remains poorly understood.
However, recent studies have begun to uncover some of the molecular pathways involved in sarcomagenesis.
The chemokine receptor CXCR4 has been implicated in sarcoma development and has been found to be a prognostic marker for poor clinical outcome.
There is growing evidence that overexpression of CXCR4 plays a significant role in development of metastatic disease, especially in directing tumor cells towards the preferential sites of metastases in sarcoma, lung and bone.
Although further investigation is necessary to validate these pathways, there is potential for clinical application, particularly in the use of pharmacologic inhibitors of CXCR4 as means of preventing sarcoma metastasis.
American Psychological Association (APA)
Kim, Roger H.& Li, Benjamin D. L.& Chu, Quyen D.. 2010. The Role of Chemokine Receptor CXCR4 in the Biologic Behavior of Human Soft Tissue Sarcoma. Complexity،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-991200
Modern Language Association (MLA)
Kim, Roger H.…[et al.]. The Role of Chemokine Receptor CXCR4 in the Biologic Behavior of Human Soft Tissue Sarcoma. Complexity No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-991200
American Medical Association (AMA)
Kim, Roger H.& Li, Benjamin D. L.& Chu, Quyen D.. The Role of Chemokine Receptor CXCR4 in the Biologic Behavior of Human Soft Tissue Sarcoma. Complexity. 2010. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-991200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991200