A “Proteoglycan Targeting Strategy” for the Scintigraphic Imaging and Monitoring of the Swarm Rat Chondrosarcoma Orthotopic Model
Joint Authors
Peyrode, Caroline
Dauplat, Marie-Mélanie
Chezal, Jean-Michel
Besse, Sophie
Askienazy, Serge
Miot-Noirault, Elisabeth
Vidal, Aurélien
Heymann, Dominique
Redini, Françoise
Gouin, F.
Auzeloux, Philippe
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Our lab developed 99mTc-NTP 15-5 radiotracer as targeting proteoglycans (PGs) for the scintigraphic imaging of joint.
This paper reports preclinical results of 99mTc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (SRC).
99mTc-NTP 15-5 imaging of SRC-bearing and sham-operated animals was performed and quantified at regular intervals after surgery and compared to bone scintigraphy and tumoural volume.
Tumours were characterized by histology and PG assay.
SRC exhibited a significant 99mTc-NTP 15-5 uptake at very early stage after implant (with tumour/muscle ratio of 1.61 ± 0.14), whereas no measurable tumour was evidenced.
As tumour grew, mean tumour/muscle ratio was increased by 2.4, between the early and late stage of pathology.
Bone scintigraphy failed to image chondrosarcoma, even at the later stage of study.
99mTc-NTP 15-5 imaging provided a suitable set of quantitative criteria for the in vivo characterization of chondrosarcoma behaviour in bone environment, useful for achieving a greater understanding of the pathology.
American Psychological Association (APA)
Peyrode, Caroline& Gouin, F.& Vidal, Aurélien& Auzeloux, Philippe& Besse, Sophie& Dauplat, Marie-Mélanie…[et al.]. 2011. A “Proteoglycan Targeting Strategy” for the Scintigraphic Imaging and Monitoring of the Swarm Rat Chondrosarcoma Orthotopic Model. Complexity،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-991208
Modern Language Association (MLA)
Peyrode, Caroline…[et al.]. A “Proteoglycan Targeting Strategy” for the Scintigraphic Imaging and Monitoring of the Swarm Rat Chondrosarcoma Orthotopic Model. Complexity No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-991208
American Medical Association (AMA)
Peyrode, Caroline& Gouin, F.& Vidal, Aurélien& Auzeloux, Philippe& Besse, Sophie& Dauplat, Marie-Mélanie…[et al.]. A “Proteoglycan Targeting Strategy” for the Scintigraphic Imaging and Monitoring of the Swarm Rat Chondrosarcoma Orthotopic Model. Complexity. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-991208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991208