Receptor Tyrosine Kinases as Therapeutic Targets in Rhabdomyosarcoma
Joint Authors
Linardic, Corinne M.
Crose, Lisa E. S.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Rhabdomyosarcomas (RMSs) are the most common soft tissue sarcomas of childhood and adolescence.
To date, there are no effective treatments that target the genetic abnormalities in RMS, and current treatment options for high-risk groups are not adequate.
Over the past two decades, research into the molecular mechanisms of RMS has identified key genes and signaling pathways involved in disease pathogenesis.
In these studies, members of the receptor tyrosine kinase (RTK) family of cell surface receptors have been characterized as druggable targets for RMS.
Through small molecule inhibitors, ligand-neutralizing agents, and monoclonal receptor-blocking antibodies, RTK activity can be manipulated to block oncogenic properties associated with RMS.
Herein, we review the members of the RTK family that are implicated in RMS tumorigenesis and discuss both the problems and promise of targeting RTKs in RMS.
American Psychological Association (APA)
Crose, Lisa E. S.& Linardic, Corinne M.. 2010. Receptor Tyrosine Kinases as Therapeutic Targets in Rhabdomyosarcoma. Complexity،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-991213
Modern Language Association (MLA)
Crose, Lisa E. S.& Linardic, Corinne M.. Receptor Tyrosine Kinases as Therapeutic Targets in Rhabdomyosarcoma. Complexity No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-991213
American Medical Association (AMA)
Crose, Lisa E. S.& Linardic, Corinne M.. Receptor Tyrosine Kinases as Therapeutic Targets in Rhabdomyosarcoma. Complexity. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-991213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991213