Advances in Molecular Characterization and Targeted Therapy in Dermatofibrosarcoma Protuberans
Joint Authors
Wozniak, Agnieszka
Switaj, Tomasz
Rutkowski, Piotr
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The molecular pathogenesis of dermatofibrosarcoma protuberans (DFSP) involves distinctive rearrangement of chromosomes 17 and 22 leading to formation of the COL1A1-PDGFB fusion gene.
The knowledge of molecular events underlying development of DFSP resulted in the implementation of targeted therapy with imatinib—a tyrosine kinase inhibitor (TKI), to the clinical practice.
The striking efficacy of imatinib in advanced cases of DFSP has been demonstrated in a few clinical trials.
Thus, imatinib is currently considered the gold standard in the treatment of inoperable and/or metastatic and/or recurrent cases of DFSP.
Therapy with imatinib may potentially facilitate resection or decrease possible disfigurement related to radical surgical procedure.
Following partial response on imatinib significant percentage of patients may be rendered free of the disease by surgery of the residual tumor.
American Psychological Association (APA)
Rutkowski, Piotr& Wozniak, Agnieszka& Switaj, Tomasz. 2011. Advances in Molecular Characterization and Targeted Therapy in Dermatofibrosarcoma Protuberans. Complexity،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-991236
Modern Language Association (MLA)
Rutkowski, Piotr…[et al.]. Advances in Molecular Characterization and Targeted Therapy in Dermatofibrosarcoma Protuberans. Complexity No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-991236
American Medical Association (AMA)
Rutkowski, Piotr& Wozniak, Agnieszka& Switaj, Tomasz. Advances in Molecular Characterization and Targeted Therapy in Dermatofibrosarcoma Protuberans. Complexity. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-991236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991236