The Molecular Pathogenesis of Osteosarcoma: A Review
Joint Authors
Myers, Damian E.
Dass, Crispin R.
Choong, Peter F. M.
Clark, Jonathan C. M.
Broadhead, Matthew L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Osteosarcoma is the most common primary malignancy of bone.
It arises in bone during periods of rapid growth and primarily affects adolescents and young adults.
The 5-year survival rate for osteosarcoma is 60%–70%, with no significant improvements in prognosis since the advent of multiagent chemotherapy.
Diagnosis, staging, and surgical management of osteosarcoma remain focused on our anatomical understanding of the disease.
As our knowledge of the molecular pathogenesis of osteosarcoma expands, potential therapeutic targets are being identified.
A comprehensive understanding of these mechanisms is essential if we are to improve the prognosis of patients with osteosarcoma through tumour-targeted therapies.
This paper will outline the pathogenic mechanisms of osteosarcoma oncogenesis and progression and will discuss some of the more frontline translational studies performed to date in search of novel, safer, and more targeted drugs for disease management.
American Psychological Association (APA)
Broadhead, Matthew L.& Clark, Jonathan C. M.& Myers, Damian E.& Dass, Crispin R.& Choong, Peter F. M.. 2011. The Molecular Pathogenesis of Osteosarcoma: A Review. Complexity،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-991238
Modern Language Association (MLA)
Broadhead, Matthew L.…[et al.]. The Molecular Pathogenesis of Osteosarcoma: A Review. Complexity No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-991238
American Medical Association (AMA)
Broadhead, Matthew L.& Clark, Jonathan C. M.& Myers, Damian E.& Dass, Crispin R.& Choong, Peter F. M.. The Molecular Pathogenesis of Osteosarcoma: A Review. Complexity. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-991238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991238