Connexin 43 Is a Potential Prognostic Biomarker for Ewing SarcomaPrimitive Neuroectodermal Tumor
Joint Authors
Zhang, Paul J.
Bui, Marilyn M.
Pasha, T. L.
Reed, Damon R.
Han, Gang
Gonzalez, Ricardo J.
Acs, Geza
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Connexins (Cxs) are building unit proteins of gap junctions (GJs) that are prognostic markers in carcinomas.
To investigate the role of Cx in Ewing sarcoma (EWS)/primitive neuroectodermal tumor (PNET), we examined the expression of Cx43 and Cx26 in 36 EWS/PNETs and found (1) cytoplasmic Cx43 reactivity in 28/36 (78%) cases.
(2) Cx43 score was significantly correlated with overall survival (P=.025).
The average scores for patients alive and dead at 3 years are 46.08 and 96.98 (P=.004) at 5 years are 46.06 and 96.42 (P=.002).
(3) Metastasis had a significant effect on the overall survival (P=.003).
(4) Cytoplasmic Cx26 reactivity was detected in 2 of 36 (6%) patients who died with metastasis.
Our results suggest a possible oncogenic and prognostic role for Cx43 and Cx26 in EWS/PNET.
The lack of membranous immunoreactivity suggests that the effect of Cx in EWS/PNET is via a GJ function-independent mechanism.
American Psychological Association (APA)
Bui, Marilyn M.& Han, Gang& Acs, Geza& Reed, Damon R.& Gonzalez, Ricardo J.& Pasha, T. L.…[et al.]. 2011. Connexin 43 Is a Potential Prognostic Biomarker for Ewing SarcomaPrimitive Neuroectodermal Tumor. Complexity،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-991240
Modern Language Association (MLA)
Bui, Marilyn M.…[et al.]. Connexin 43 Is a Potential Prognostic Biomarker for Ewing SarcomaPrimitive Neuroectodermal Tumor. Complexity No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-991240
American Medical Association (AMA)
Bui, Marilyn M.& Han, Gang& Acs, Geza& Reed, Damon R.& Gonzalez, Ricardo J.& Pasha, T. L.…[et al.]. Connexin 43 Is a Potential Prognostic Biomarker for Ewing SarcomaPrimitive Neuroectodermal Tumor. Complexity. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-991240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991240