Regulation of Neutrophil SurvivalApoptosis by Mcl-1
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Neutrophil granulocytes have the shortest lifespan among leukocytes in the circulation and die via apoptosis.
At sites of infection or tissue injury, prolongation of neutrophil lifespan is critical for effective host defense.
Apoptosis of inflammatory neutrophils and their clearance are critical control points for termination of the inflammatory response.
Evasion of neutrophil apoptosis aggravates local injury and leads to persistent tissue damage.
The short-lived prosurvival Bcl-2 family protein, Mcl-1 (myeloid cell leukemia-1), is instrumental in controlling apoptosis and consequently neutrophil lifespan in response to rapidly changing environmental cues during inflammation.
This paper will focus on multiple levels of control of Mcl-1 expression and function and will discuss targeting Mcl-1 as a potential therapeutic strategy to enhance the resolution of inflammation through accelerating neutrophil apoptosis.
American Psychological Association (APA)
Milot, Eric& Filep, János G.. 2011. Regulation of Neutrophil SurvivalApoptosis by Mcl-1. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-991250
Modern Language Association (MLA)
Milot, Eric& Filep, János G.. Regulation of Neutrophil SurvivalApoptosis by Mcl-1. The Scientific World Journal No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-991250
American Medical Association (AMA)
Milot, Eric& Filep, János G.. Regulation of Neutrophil SurvivalApoptosis by Mcl-1. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-991250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991250