Serotonergic Dysfunction in Parkinson's Disease and Its Relevance to Disability
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Growing evidence suggests that Parkinson's disease is not solely affecting the dopaminergic system.
Results from biochemical, animal, postmortem, and functional imaging studies have revealed that other neurotransmitter systems are affected as well, including the serotonergic system.
With the use of in vivo positron emission tomography functional imaging, it has been shown that serotonergic terminals are affected at a varying, nonlinear degree starting early in the clinical course of Parkinson's disease.
Tremor and the majority of nonmotor symptoms do not seem to respond adequately to dopaminergic medication.
Recent studies suggest that serotonergic dysfunction has a direct relevance to Parkinson's disease symptoms, the so-called nonmotor symptoms, including depression, fatigue, weight changes, and visual hallucinations.
These in vivo findings indicate that agents acting on the serotonergic system could help towards alleviating these symptoms.
This paper aims to review the current literature and to highlight the need for further in vivo investigations.
American Psychological Association (APA)
Politis, Marios& Loane, Clare. 2011. Serotonergic Dysfunction in Parkinson's Disease and Its Relevance to Disability. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-991254
Modern Language Association (MLA)
Politis, Marios& Loane, Clare. Serotonergic Dysfunction in Parkinson's Disease and Its Relevance to Disability. The Scientific World Journal No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-991254
American Medical Association (AMA)
Politis, Marios& Loane, Clare. Serotonergic Dysfunction in Parkinson's Disease and Its Relevance to Disability. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-991254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991254