Macrophage Polarization in Health and Disease
Joint Authors
Poli, Guido
Cassetta, Luca
Cassol, Edana
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Macrophages are terminally differentiated cells of the mononuclear phagocyte system that also encompasses dendritic cells, circulating blood monocytes, and committed myeloid progenitor cells in the bone marrow.
Both macrophages and their monocytic precursors can change their functional state in response to microenvironmental cues exhibiting a marked heterogeneity.
However, there are still uncertainties regarding distinct expression patterns of surface markers that clearly define macrophage subsets, particularly in the case of human macrophages.
In addition to their tissue distribution, macrophages can be functionally polarized into M1 (proinflammatory) and M2 (alternatively activated) as well as regulatory cells in response to both exogenous infections and solid tumors as well as by systems biology approaches.
American Psychological Association (APA)
Cassetta, Luca& Cassol, Edana& Poli, Guido. 2011. Macrophage Polarization in Health and Disease. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-991257
Modern Language Association (MLA)
Cassetta, Luca…[et al.]. Macrophage Polarization in Health and Disease. The Scientific World Journal No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-991257
American Medical Association (AMA)
Cassetta, Luca& Cassol, Edana& Poli, Guido. Macrophage Polarization in Health and Disease. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-991257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991257