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Macrophages, Meta-Inflammation, and Immuno-Metabolism
Joint Authors
Shapiro, Haim
Lutaty, Aviv
Ariel, Amiram
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-28
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Current research depicts specific modes of immunity and energy metabolism as being interrelated at the molecular, cellular, organ and organism level.
Hence, whereas M2 (alternatively-activated) macrophages dominate insulin-sensitive adipose tissue in the lean, M1-skewed (classically-activated) macrophages accumulate in parallel to adiposity in the obese, and promote inflammation and insulin resistance, that is, meta-inflammation.
The latest frontier of immuno-metabolism explores the coregulation of energy metabolism and immune function within hematopoietic cells.
M1-skewed macrophages are sustained in edematous, hypoxic tissues by anaerobic glycolysis, whereas mitochondrial biogenesis and respiration dominates in M2 cells.
We review the underlying mechanisms and the consequences of the transition from M2 to M1 predominance in adipose tissue, as well as the extracellular signals and transcription factors that control macrophage phenotypes and impose distinct metabolic modes.
American Psychological Association (APA)
Shapiro, Haim& Lutaty, Aviv& Ariel, Amiram. 2011. Macrophages, Meta-Inflammation, and Immuno-Metabolism. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-991299
Modern Language Association (MLA)
Shapiro, Haim…[et al.]. Macrophages, Meta-Inflammation, and Immuno-Metabolism. The Scientific World Journal No. 2011 (2011), pp.1-21.
https://search.emarefa.net/detail/BIM-991299
American Medical Association (AMA)
Shapiro, Haim& Lutaty, Aviv& Ariel, Amiram. Macrophages, Meta-Inflammation, and Immuno-Metabolism. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-991299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991299