The Role of CD40CD40 Ligand Interactions in Bone Marrow Granulopoiesis
Joint Authors
Papadaki, Helen A.
Mavroudi, Irene
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The CD40 ligand (CD40L) and CD40 are two molecules belonging to the TNF/TNF receptor superfamily, and their role in adaptive immune system has widely been explored.
However, the wide range of expression of these molecules on hematopoietic as well as nonhematopoietic cells has revealed multiple functions of the CD40/CD40L interactions on different cell types and processes such as granulopoiesis.
CD40 triggering on stromal cells has been documented to enhance the expression of granulopoiesis growth factors such as granulocyte-colony-stimulating factor (G-CSF) and granulocyte/monocyte-colony-stimulating factor (GM-CSF), and upon disruption of the CD40/CD40L-signaling pathway, as in the case of X-linked hyperimmunoglobulin M (IgM) syndrome (XHIGM), it can lead to neutropenia.
In chronic idiopathic neutropenia (CIN) of adults, however, under the influence of an inflammatory microenvironment, CD40L plays a role in granulocytic progenitor cell depletion, providing thus a pathogenetic cause of CIN.
American Psychological Association (APA)
Mavroudi, Irene& Papadaki, Helen A.. 2011. The Role of CD40CD40 Ligand Interactions in Bone Marrow Granulopoiesis. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-991348
Modern Language Association (MLA)
Mavroudi, Irene& Papadaki, Helen A.. The Role of CD40CD40 Ligand Interactions in Bone Marrow Granulopoiesis. The Scientific World Journal No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-991348
American Medical Association (AMA)
Mavroudi, Irene& Papadaki, Helen A.. The Role of CD40CD40 Ligand Interactions in Bone Marrow Granulopoiesis. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-991348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991348