Obesity, Inflammation, and Postmenopausal Breast Cancer: Therapeutic Implications
Joint Authors
Madeddu, Clelia
Maccio, Antonio
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-27
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Breast cancer is the female malignant neoplasia with the highest incidence in the industrialized world.
Although early diagnosis has contributed to therapeutic success, breast cancer remains a major health issue.
In the last few year the hormone therapy for estrogen-dependent breast cancer has evolved achieving significant clinical results; at the same time, it has enabled us to better define the role of estrogens in the etiopathogenesis of this tumour.
Weight increase and obesity have been identified as the most important risk and prognostic factors for breast cancer in postmenopausal women.
Several hypotheses have been proposed to explain the association of obesity with postmenopausal breast cancer.
Specific obesity-associated factors, including leptin, insulin and inflammatory mediators, seem to influence breast cancer growth and prognosis independently of estrogens and at least in part by interacting with estrogen signalling at a cellular level.
Therefore, a careful assessment of the nutritional status and body composition is paramount for a proper therapeutic approach for postmenopausal breast carcinoma.
The use of antidiabetic and anti-inflammatory drugs associated with conventional hormone therapies and dietary/physical interventions could offer a new therapeutic approach for breast carcinoma that develops in the context of adiposity.
American Psychological Association (APA)
Maccio, Antonio& Madeddu, Clelia. 2011. Obesity, Inflammation, and Postmenopausal Breast Cancer: Therapeutic Implications. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-991387
Modern Language Association (MLA)
Maccio, Antonio& Madeddu, Clelia. Obesity, Inflammation, and Postmenopausal Breast Cancer: Therapeutic Implications. The Scientific World Journal No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-991387
American Medical Association (AMA)
Maccio, Antonio& Madeddu, Clelia. Obesity, Inflammation, and Postmenopausal Breast Cancer: Therapeutic Implications. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-991387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991387