An Overview of DNA Repair in Amyotrophic Lateral Sclerosis
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is an adult onset neurodegenerative disorder characterised by the degeneration of cortical and spinal cord motor neurons, resulting in progressive muscular weakness and death.
Increasing evidence supports mitochondrial dysfunction and oxidative DNA damage in ALS motor neurons.
Several DNA repair enzymes are activated following DNA damage to restore genome integrity, and impairments in DNA repair capabilities could contribute to motor neuron degeneration.
After a brief description of the evidence of DNA damage in ALS, this paper focuses on the available data on DNA repair activity in ALS neuronal tissue and disease animal models.
Moreover, biochemical and genetic data on DNA repair in ALS are discussed in light of similar findings in other neurodegenerative diseases.
American Psychological Association (APA)
Coppedè, Fabio. 2011. An Overview of DNA Repair in Amyotrophic Lateral Sclerosis. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-991388
Modern Language Association (MLA)
Coppedè, Fabio. An Overview of DNA Repair in Amyotrophic Lateral Sclerosis. The Scientific World Journal No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-991388
American Medical Association (AMA)
Coppedè, Fabio. An Overview of DNA Repair in Amyotrophic Lateral Sclerosis. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-991388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991388