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Memory-Enhancing Activity of Palmatine in Mice Using Elevated Plus Maze and Morris Water Maze
Joint Authors
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study was designed to evaluate the effect of palmatine on memory of Swiss young male albino mice.
Palmatine (0.1, 0.5, 1 mg/kg, i.p.) and physostigmine (0.1 mg/kg, i.p.) per se were administered for 10 successive days to separate groups of mice.
Effect of drugs on learning and memory of mice was evaluated using elevated plus maze and Morris water maze.
Brain acetylcholinesterase activity was also estimated.
Effect of palmatine on scopolamine- and diazepam-induced amnesia was also investigated.
Palmatine (0.5 and 1 mg/kg) and physostigmine significantly improved learning and memory of mice, as indicated by decrease in transfer latency using elevated plus maze, and decrease in escape latency during training and increase in time spent in target quadrant during retrieval using Morris water maze.
The drugs did not show any significant effect on locomotor activity of the mice.
Memory-enhancing activity of palmatine (1 mg/kg) was comparable to physostigmine.
Palmatine (1 mg/kg) significantly reversed scopolamine- and diazepam-induced amnesia in mice.
Palmatine and physostigmine also significantly reduced brain acetylcholinesterase activity of mice.
Thus, palmatine showed memory-enhancing activity in mice probably by inhibiting brain acetylcholinesterase activity, through involvement of GABA-benzodiazepine pathway, and due to its antioxidant activity.
American Psychological Association (APA)
Dhingra, Dinesh& Kumar, Varun. 2012. Memory-Enhancing Activity of Palmatine in Mice Using Elevated Plus Maze and Morris Water Maze. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991424
Modern Language Association (MLA)
Dhingra, Dinesh& Kumar, Varun. Memory-Enhancing Activity of Palmatine in Mice Using Elevated Plus Maze and Morris Water Maze. Advances in Pharmacological and Pharmaceutical Sciences No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-991424
American Medical Association (AMA)
Dhingra, Dinesh& Kumar, Varun. Memory-Enhancing Activity of Palmatine in Mice Using Elevated Plus Maze and Morris Water Maze. Advances in Pharmacological and Pharmaceutical Sciences. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991424