Methanolic Root Extract of Rauwolfia serpentina Benth Improves the Glycemic, Antiatherogenic, and Cardioprotective Indices in Alloxan-Induced Diabetic Mice
Joint Authors
Azmi, Muhammad Bilal
Qureshi, Shamim A.
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of the study was to evaluate the phytochemistry and the effect of methanolic root extract (MREt) of Rauwolfia serpentina on alloxan-induced diabetic Wister male mice.
Mice were divided in control (distilled water at 1 mL/kg) and alloxan-induced diabetic mice which subdivided into diabetic (distilled water at 1 mL/kg), negative (0.05% dimethyl sulfoxide at 1 mL/kg), positive (glibenclamide at 5 mg/kg) controls, and three test groups (MREt at 10, 30, and 60 mg/kg).
All treatments were given orally for 14 days.
Qualitatively MREt showed the presence of alkaloids, carbohydrates, flavonoids, glycosides, cardiac glycosides, phlobatannins, resins, saponins, steroids, tannins, and triterpenoids, while quantitatively extract was rich in total phenols.
The flavonoids, saponins and alkaloids were also determined in root powder.
MREt found effective in improving the body weights, glucose and insulin levels, insulin/glucose ratio, glycosylated and total hemoglobin in test groups as compared to diabetic control.
Similarly, significantly decreased levels of total cholesterol, triglycerides, low-density lipoprotein (LDL-c), and very low-density lipoprotein (VLDL-c) cholesterols were found in test groups.
Significant lipolysis with improved glycogenesis was also found in liver tissues of all test groups.
ALT levels were found normal in all groups.
Thus, MREt improves the glycemic, antiatherogenic, coronary risk, and cardioprotective indices in alloxan-induced diabetic mice.
American Psychological Association (APA)
Azmi, Muhammad Bilal& Qureshi, Shamim A.. 2012. Methanolic Root Extract of Rauwolfia serpentina Benth Improves the Glycemic, Antiatherogenic, and Cardioprotective Indices in Alloxan-Induced Diabetic Mice. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-991425
Modern Language Association (MLA)
Azmi, Muhammad Bilal& Qureshi, Shamim A.. Methanolic Root Extract of Rauwolfia serpentina Benth Improves the Glycemic, Antiatherogenic, and Cardioprotective Indices in Alloxan-Induced Diabetic Mice. Advances in Pharmacological and Pharmaceutical Sciences No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-991425
American Medical Association (AMA)
Azmi, Muhammad Bilal& Qureshi, Shamim A.. Methanolic Root Extract of Rauwolfia serpentina Benth Improves the Glycemic, Antiatherogenic, and Cardioprotective Indices in Alloxan-Induced Diabetic Mice. Advances in Pharmacological and Pharmaceutical Sciences. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-991425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991425