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Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment
Joint Authors
Rahimi, Motahare
Naghibi, Sayede Maryam
Aghaie, Azita
Khani, Fatemeh
Hosseini, Mahmoud
Vafaee Bagheri, Farzaneh
Rakhshandeh, Hassan
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In the present study, the effect of aqueous extracts of saffron on morphine-induced memory impairment was investigated.
On the training trial, the mice received an electric shock when the animals were entered into the dark compartment.
Twenty-four and forty-eight hours later, the time latency for entering the dark compartment was recorded and defined as the retention trial.
The mice were divided into (1) control, (2) morphine which received morphine before the training in the passive avoidance test, (3–5) three groups treated by 50, 150 and 450 mg/kg of saffron extract before the training trial, and (6 and 7) the two other groups received 150 and 450 mg/kg of saffron extract before the retention trial.
The time latency in morphine-treated group was lower than control (P < 0.01).
Treatment of the animals by 150 and 450 mg/kg of saffron extract before the training trial increased the time latency at 24 and 48 hours after the training trial (P < 0.05 and P < 0.01).
Administration of both 150 and 450 mg/kg doses of the extract before retention trials also increased the time latency (P < 0.01).
The results revealed that the saffron extract attenuated morphine-induced memory impairment.
American Psychological Association (APA)
Naghibi, Sayede Maryam& Hosseini, Mahmoud& Khani, Fatemeh& Rahimi, Motahare& Vafaee Bagheri, Farzaneh& Rakhshandeh, Hassan…[et al.]. 2012. Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991428
Modern Language Association (MLA)
Naghibi, Sayede Maryam…[et al.]. Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment. Advances in Pharmacological and Pharmaceutical Sciences No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-991428
American Medical Association (AMA)
Naghibi, Sayede Maryam& Hosseini, Mahmoud& Khani, Fatemeh& Rahimi, Motahare& Vafaee Bagheri, Farzaneh& Rakhshandeh, Hassan…[et al.]. Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment. Advances in Pharmacological and Pharmaceutical Sciences. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991428