The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis
Joint Authors
Shuid, Ahmad Nazrun
Nadia, M. E.
Ima-Nirwana, Soelaiman
Mohamed, Norazlina
Muhammad, Norliza
Isa, N. M.
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Osteoporosis is characterized by skeletal degeneration with low bone mass and destruction of microarchitecture of bone tissue which is attributed to various factors including inflammation.
Women are more likely to develop osteoporosis than men due to reduction in estrogen during menopause which leads to decline in bone-formation and increase in bone-resorption activity.
Estrogen is able to suppress production of proinflammatory cytokines such as IL-1, IL-6, IL-7, and TNF-α.
This is why these cytokines are elevated in postmenopausal women.
Studies have shown that estrogen reduction is able to stimulate focal inflammation in bone.
Labisia pumila (LP) which is known to exert phytoestrogenic effect can be used as an alternative to ERT which can produce positive effects on bone without causing side effects.
LP contains antioxidant as well as exerting anti-inflammatory effect which can act as free radical scavenger, thus inhibiting TNF-α production and COX-2 expression which leads to decline in RANKL expression, resulting in reduction in osteoclast activity which consequently reduces bone loss.
Hence, it is the phytoestrogenic, anti-inflammatory, and antioxidative properties that make LP an effective agent against osteoporosis.
American Psychological Association (APA)
Nadia, M. E.& Shuid, Ahmad Nazrun& Mohamed, Norazlina& Isa, N. M.& Muhammad, Norliza& Ima-Nirwana, Soelaiman. 2012. The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991433
Modern Language Association (MLA)
Nadia, M. E.…[et al.]. The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis. Advances in Pharmacological and Pharmaceutical Sciences No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-991433
American Medical Association (AMA)
Nadia, M. E.& Shuid, Ahmad Nazrun& Mohamed, Norazlina& Isa, N. M.& Muhammad, Norliza& Ima-Nirwana, Soelaiman. The Anti-Inflammatory, Phytoestrogenic, and Antioxidative Role of Labisia pumila in Prevention of Postmenopausal Osteoporosis. Advances in Pharmacological and Pharmaceutical Sciences. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991433