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Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats
Joint Authors
Suzuki, Tadahiko
Hossain, Muhammad Mubarak
Kobayashi, Haruo
Imanishi, Tamotsu
Sato, Itaru
Xu, Ping
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Anticholinesterases (antiChEs) are used to treat Alzheimer’s disease.
The comparative effects of two antiChEs, methanesulfonyl fluoride (MSF) and donepezil, on the extracellular levels of ACh in the hippocampus were investigated by in vivo microdialysis in freely moving rats.
MSF at 1 and 2 mg/kg produced a dose-dependent increase in ACh efflux from 10 min to at least 3 hrs after injection.
At 2 mg/kg, the increase was still present at 24 hr.
Donepezil at 1 mg/kg showed a similar but smaller effect, and, paradoxically, 2 mg/kg showed no consistent effect.
MSF at 1 and 2 mg/kg decreased acetylcholinesterase activity in the hippocampus to 54.8 and 20.1% of control, respectively.
These results suggest that MSF is a suitable candidate for the treatment of Alzheimer’s disease.
American Psychological Association (APA)
Imanishi, Tamotsu& Hossain, Muhammad Mubarak& Suzuki, Tadahiko& Xu, Ping& Sato, Itaru& Kobayashi, Haruo. 2012. Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-991434
Modern Language Association (MLA)
Imanishi, Tamotsu…[et al.]. Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-991434
American Medical Association (AMA)
Imanishi, Tamotsu& Hossain, Muhammad Mubarak& Suzuki, Tadahiko& Xu, Ping& Sato, Itaru& Kobayashi, Haruo. Effect of a CNS-Sensitive Anticholinesterase Methane Sulfonyl Fluoride on Hippocampal Acetylcholine Release in Freely Moving Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-991434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991434