Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair
Joint Authors
Wilson, Linda
AlJamal-Naylor, Rehab
McIntyre, Susan
Harrison, David J.
Harrison, Beth
Rossi, Fiona
Marsden, Mark
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The cellular cytoskeleton, adhesion receptors, extracellular matrix composition, and their spatial distribution are together fundamental in a cell's balanced mechanical sensing of its environment.
We show that, in lung injury, extracellular matrix-integrin interactions are altered and this leads to signalling alteration and mechanical missensing.
The missensing, secondary to matrix alteration and cell surface receptor alterations, leads to increased cellular stiffness, injury, and death.
We have identified a monoclonal antibody against β1 integrin which caused matrix remodelling and enhancement of cell survival.
The antibody acts as an allosteric dual agonist/antagonist modulator of β1 integrin.
Intriguingly, this antibody reversed both functional and structural tissue injury in an animal model of degenerative disease in lung.
American Psychological Association (APA)
AlJamal-Naylor, Rehab& Wilson, Linda& McIntyre, Susan& Rossi, Fiona& Harrison, Beth& Marsden, Mark…[et al.]. 2012. Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-991436
Modern Language Association (MLA)
AlJamal-Naylor, Rehab…[et al.]. Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair. Advances in Pharmacological and Pharmaceutical Sciences No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-991436
American Medical Association (AMA)
AlJamal-Naylor, Rehab& Wilson, Linda& McIntyre, Susan& Rossi, Fiona& Harrison, Beth& Marsden, Mark…[et al.]. Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair. Advances in Pharmacological and Pharmaceutical Sciences. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-991436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991436