Chronic Administration of a Combination of Six Herbs Inhibits the Progression of Hyperglycemia and Decreases Serum Lipids and Aspartate Amino Transferase Activity in Diabetic Rats
Joint Authors
Ghorbani, Ahmad
Shafiee-Nick, Reza
Vafaee Bagheri, Farzaneh
Rakhshandeh, Hassan
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The effects of a polyherbal compound, containing six plants (Allium sativum, Cinnamomum zeylanicum, Nigella sativa, Punica granatum, Salvia officinalis and Teucrium polium) were tested on biochemical parameters in streptozotocin-induced diabetic rats.
Streptozotocin caused an approximately 3-fold increase in fasting blood sugar level after 2 days.
The diabetic control rats showed further increase in blood glucose after 30 days (384 ± 25 mg/dl in day 30 versus 280 ± 12 mg/dl in day 2, P<0.001).
Administration of the compound blocked the increase of blood glucose (272 ± 7 and 269 ± 48 mg/dl at day 2 and day 30, respectively).
Also, there was significant difference in the level of triglyceride (60 ± 9 versus 158 ± 37 mg/dl, P<0.01), total cholesterol (55 ± 2 versus 97 ± 11 mg/dl, P < 0.01) and aspartate amino transferase activity (75 ± 12 versus 129 ± 18 U/L, P<0.05) between treated rats and diabetic control group.
In conclusion, the MSEC inhibited the progression of hyperglycemia and decreased serum lipids and hepatic enzyme activity in diabetic rats.
Therefore, it has the potential to be used as a natural product for the management of diabetes.
American Psychological Association (APA)
Shafiee-Nick, Reza& Ghorbani, Ahmad& Vafaee Bagheri, Farzaneh& Rakhshandeh, Hassan. 2012. Chronic Administration of a Combination of Six Herbs Inhibits the Progression of Hyperglycemia and Decreases Serum Lipids and Aspartate Amino Transferase Activity in Diabetic Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991438
Modern Language Association (MLA)
Shafiee-Nick, Reza…[et al.]. Chronic Administration of a Combination of Six Herbs Inhibits the Progression of Hyperglycemia and Decreases Serum Lipids and Aspartate Amino Transferase Activity in Diabetic Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-991438
American Medical Association (AMA)
Shafiee-Nick, Reza& Ghorbani, Ahmad& Vafaee Bagheri, Farzaneh& Rakhshandeh, Hassan. Chronic Administration of a Combination of Six Herbs Inhibits the Progression of Hyperglycemia and Decreases Serum Lipids and Aspartate Amino Transferase Activity in Diabetic Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991438