A Novel Model of Atherosclerosis in Rabbits Using Injury to Arterial Walls Induced by Ferric Chloride as Evaluated by Optical Coherence Tomography as well as Intravascular Ultrasound and Histology
Joint Authors
Tian, Jinwei
Hu, Sining
Yu, Bo
Dong, Nana
Ban, Xiang
Yu, Huai
Wu, Jian
Sun, Yanli
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study aim was to develop a new model of atherosclerosis by FeCl3-induced injury to right common carotid arteries (CCAs) of rabbits.
Right CCAs were induced in male New Zealand White rabbits (n=15) by combination of a cholesterol-rich diet and FeCl3-induced injury to arterial walls.
The right and left CCAs were evaluated by histology and in vivo intravascular ultrasound (IVUS) and optical coherence tomography (OCT) examinations of 24 hours (n=3), 8 weeks (n=6), and 12 weeks (n=6) after injury.
Each right CCA of the rabbits showed extensive white-yellow plaques.
At eight and 12 weeks after injury, IVUS, OCT, and histological findings demonstrated that the right CCAs had evident eccentric plaques.
Six plaques (50%) with evident positive remodeling were observed.
Marked progression was clearly observed in the same plaque at 12 weeks after injury when it underwent repeat OCT and IVUS.
We demonstrated, for the first time, a novel model of atherosclerosis induced by FeCl3.
The model is simple, fast, inexpensive, and reproducible and has a high success rate.
The eccentric plaques and remodeling of plaques were common in this model.
We successfully carried out IVUS and OCT examinations twice in the same lesion within a relatively long period of time.
American Psychological Association (APA)
Tian, Jinwei& Hu, Sining& Sun, Yanli& Ban, Xiang& Yu, Huai& Dong, Nana…[et al.]. 2012. A Novel Model of Atherosclerosis in Rabbits Using Injury to Arterial Walls Induced by Ferric Chloride as Evaluated by Optical Coherence Tomography as well as Intravascular Ultrasound and Histology. BioMed Research International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991455
Modern Language Association (MLA)
Tian, Jinwei…[et al.]. A Novel Model of Atherosclerosis in Rabbits Using Injury to Arterial Walls Induced by Ferric Chloride as Evaluated by Optical Coherence Tomography as well as Intravascular Ultrasound and Histology. BioMed Research International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-991455
American Medical Association (AMA)
Tian, Jinwei& Hu, Sining& Sun, Yanli& Ban, Xiang& Yu, Huai& Dong, Nana…[et al.]. A Novel Model of Atherosclerosis in Rabbits Using Injury to Arterial Walls Induced by Ferric Chloride as Evaluated by Optical Coherence Tomography as well as Intravascular Ultrasound and Histology. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991455