Bone Marrow Microenvironment in Multiple Myeloma Progression
Joint Authors
Roccaro, A. M.
Sacco, A.
Ghobrial, I. M.
Manier, S.
Leleu, X.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment.
Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells.
The BM niche is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a noncellular compartment including the extracellular matrix (ECM) and the liquid milieu (cytokines, growth factors, and chemokines).
In this paper we discuss how the interaction between the malignant plasma cell and the BM microenvironment allowed myeloma progression through cell homing and the new concept of premetastatic niche.
American Psychological Association (APA)
Manier, S.& Sacco, A.& Leleu, X.& Ghobrial, I. M.& Roccaro, A. M.. 2012. Bone Marrow Microenvironment in Multiple Myeloma Progression. BioMed Research International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-991471
Modern Language Association (MLA)
Manier, S.…[et al.]. Bone Marrow Microenvironment in Multiple Myeloma Progression. BioMed Research International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-991471
American Medical Association (AMA)
Manier, S.& Sacco, A.& Leleu, X.& Ghobrial, I. M.& Roccaro, A. M.. Bone Marrow Microenvironment in Multiple Myeloma Progression. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-991471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991471