Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury
Joint Authors
Zhao, Min
Li, Tiegang
Wang, Nana
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Phosphocreatine (PCr) is a natural compound, which can donate high-energy phosphate group to ADP to synthesize ATP, even in the absence of oxygen and glucose.
At present, it is widely used in cardiac and renal ischemia-reperfusion (IR) disease.
In this study, to examine the protective efficacy of PCr against cerebral IR, disodium creatine phosphate was injected intravenously into rats before focal cerebral IR.
Intracranial pressure (ICP), neurological score, cerebral infarction volume, and apoptotic neurons were observed.
Expression of caspase-3 and aquaporin-4 (AQP4) was analyzed.
Compared with IR group, rats pretreated with PCr had better neurologic score, less infarction volume, fewer ultrastructural histopathologic changes, reduced apoptosis, and lower aquaporin-4 level.
In conclusion, PCr is neuroprotective after transient focal cerebral IR injury.
Such a protection might be associated with apoptosis regulating proteins.
American Psychological Association (APA)
Li, Tiegang& Wang, Nana& Zhao, Min. 2012. Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury. BioMed Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991478
Modern Language Association (MLA)
Li, Tiegang…[et al.]. Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury. BioMed Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-991478
American Medical Association (AMA)
Li, Tiegang& Wang, Nana& Zhao, Min. Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991478