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An Integrative Approach to Infer Regulation Programs in aTranscription Regulatory Module Network
Joint Authors
Qi, Jianlong
Michoel, Tom
Butler, Gregory
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The module network method, a special type of Bayesian network algorithms, has been proposed to infer transcription regulatory networks from gene expression data.
In this method, a module represents a set of genes, which have similar expression profiles and are regulated by same transcription factors.
The process of learning module networks consists of two steps: first clustering genes into modules and then inferring the regulation program (transcription factors) of each module.
Many algorithms have been designed to infer the regulation program of a given gene module, and these algorithms show very different biases in detecting regulatory relationships.
In this work, we explore the possibility of integrating results from different algorithms.
The integration methods we select are union, intersection, and weighted rank aggregation.
Experiments in a yeast dataset show that the union and weighted rank aggregation methods produce more accurate predictions than those given by individual algorithms, whereas the intersection method does not yield any improvement in the accuracy of predictions.
In addition, somewhat surprisingly, the union method, which has a lower computational cost than rank aggregation, achieves comparable results as given by rank aggregation.
American Psychological Association (APA)
Qi, Jianlong& Michoel, Tom& Butler, Gregory. 2012. An Integrative Approach to Infer Regulation Programs in aTranscription Regulatory Module Network. BioMed Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-991510
Modern Language Association (MLA)
Qi, Jianlong…[et al.]. An Integrative Approach to Infer Regulation Programs in aTranscription Regulatory Module Network. BioMed Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-991510
American Medical Association (AMA)
Qi, Jianlong& Michoel, Tom& Butler, Gregory. An Integrative Approach to Infer Regulation Programs in aTranscription Regulatory Module Network. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-991510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991510