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MarVis-Filter: Ranking, Filtering, Adduct and Isotope Correction of Mass Spectrometry Data
Joint Authors
Feussner, Ivo
Kaever, Alexander
Possienke, Mareike
Landesfeind, Manuel
Meinicke, Peter
Feussner, Kirstin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Statistical ranking, filtering, adduct detection, isotope correction, and molecular formula calculation are essential tasks in processing mass spectrometry data in metabolomics studies.
In order to obtain high-quality data sets, a framework which incorporates all these methods is required.
We present the MarVis-Filter software, which provides well-established and specialized methods for processing mass spectrometry data.
For the task of ranking and filtering multivariate intensity profiles, MarVis-Filter provides the ANOVA and Kruskal-Wallis tests with adjustment for multiple hypothesis testing.
Adduct and isotope correction are based on a novel algorithm which takes the similarity of intensity profiles into account and allows user-defined ionization rules.
The molecular formula calculation utilizes the results of the adduct and isotope correction.
For a comprehensive analysis, MarVis-Filter provides an interactive interface to combine data sets deriving from positive and negative ionization mode.
The software is exemplarily applied in a metabolic case study, where octadecanoids could be identified as markers for wounding in plants.
American Psychological Association (APA)
Kaever, Alexander& Landesfeind, Manuel& Possienke, Mareike& Feussner, Kirstin& Feussner, Ivo& Meinicke, Peter. 2012. MarVis-Filter: Ranking, Filtering, Adduct and Isotope Correction of Mass Spectrometry Data. BioMed Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991608
Modern Language Association (MLA)
Kaever, Alexander…[et al.]. MarVis-Filter: Ranking, Filtering, Adduct and Isotope Correction of Mass Spectrometry Data. BioMed Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-991608
American Medical Association (AMA)
Kaever, Alexander& Landesfeind, Manuel& Possienke, Mareike& Feussner, Kirstin& Feussner, Ivo& Meinicke, Peter. MarVis-Filter: Ranking, Filtering, Adduct and Isotope Correction of Mass Spectrometry Data. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991608