Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract

Joint Authors

Tsia, Yu-Ting
Hsu, Chih-Ping
Huang, Chiu-Chen
Lin, Yi-Hsien
Chou, Jyh-Ching
Su, Jhih-Rou
Lin, Chih-Cheng
Chung, Yuan-Chiang

Source

BioMed Research International

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-10-03

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

The Litchi (Litchi chinensis) fruit products possess rich amounts of flavanoids and proanthocyanidins.

Its pericarp has been shown to inhibit breast and liver cancer cell growth.

However, the anticolorectal cancer effect of Litchi seed extract has not yet been reported.

In this study, the effects of polyphenol-rich Litchi seed ethanol extract (LCSP) on the proliferation, cell cycle, and apoptosis of two colorectal cancer cell lines Colo320DM and SW480 were examined.

The results demonstrated that LCSP significantly induced apoptotic cell death in a dose-dependent manner and arrested cell cycle in G2/M in colorectal carcinoma cells.

LCSP also suppressed cyclins and elevated the Bax : Bcl-2 ratio and caspase 3 activity.

This study provides in vitro evidence that LCSP serves as a potential chemopreventive agent for colorectal cancer.

American Psychological Association (APA)

Hsu, Chih-Ping& Lin, Chih-Cheng& Huang, Chiu-Chen& Lin, Yi-Hsien& Chou, Jyh-Ching& Tsia, Yu-Ting…[et al.]. 2012. Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract. BioMed Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991643

Modern Language Association (MLA)

Hsu, Chih-Ping…[et al.]. Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract. BioMed Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-991643

American Medical Association (AMA)

Hsu, Chih-Ping& Lin, Chih-Cheng& Huang, Chiu-Chen& Lin, Yi-Hsien& Chou, Jyh-Ching& Tsia, Yu-Ting…[et al.]. Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991643

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-991643