A Standardized Extract of Ginkgo biloba Neutralizes Cisplatin-Mediated Reproductive Toxicity in Rats
Joint Authors
Abraham, Christeena
Harethi, Saina S.
Daoud, Sayel
al-Shamsi, Shaikha B.
Abdalla, Zeinab A.
Hamza, Alaaeldin A.
Amin, Amr
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of this study was to evaluate the protective effects of Ginkgo biloba (GB) against testicular damage and oxidative stress as well as caudal sperm indices in a cisplatin- (CIS-) induced rodent model.
Adult male Wistar rats were given vehicle, single i.p.
dose of CIS alone (10 mg/kg), GB alone (200 mg g/kg every day for five days), or single dose of CIS followed by GB (50, 100, or 200 mg/kg every day for five days).
On day 6, after the first drug treatment oxidative and apoptotic testicular toxicity was evaluated.
CIS-treated rats displayed decreased weights of testes and epididymis as well as caudal sperm count and motility.
This reproductive toxicity was accompanied with increased germ-cell degeneration in seminiferous tubules and increased germ-cell apoptosis, increased testicular MDA levels and MPO activity, and decreased SOD and CAT activities in testes.
Intensive expressions of COX-2, iNOS, and NF-κB p65 in testicular tissues were detected in CIS-treated group.
Oral GB administrations at all doses to CIS-treated rats effectively alleviated all of the CIS-induced toxicity in reproductive system.
The present results provide further insights into the mechanisms of protection against CIS-induced reproductive toxicity and confirm the essential antioxidant potential of a GB extract.
American Psychological Association (APA)
Amin, Amr& Abraham, Christeena& Hamza, Alaaeldin A.& Abdalla, Zeinab A.& al-Shamsi, Shaikha B.& Harethi, Saina S.…[et al.]. 2012. A Standardized Extract of Ginkgo biloba Neutralizes Cisplatin-Mediated Reproductive Toxicity in Rats. BioMed Research International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-991658
Modern Language Association (MLA)
Amin, Amr…[et al.]. A Standardized Extract of Ginkgo biloba Neutralizes Cisplatin-Mediated Reproductive Toxicity in Rats. BioMed Research International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-991658
American Medical Association (AMA)
Amin, Amr& Abraham, Christeena& Hamza, Alaaeldin A.& Abdalla, Zeinab A.& al-Shamsi, Shaikha B.& Harethi, Saina S.…[et al.]. A Standardized Extract of Ginkgo biloba Neutralizes Cisplatin-Mediated Reproductive Toxicity in Rats. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-991658
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991658