The Role of Nephritis-Associated Plasmin Receptor (NAPlr) in Glomerulonephritis Associated with Streptococcal Infection
Joint Authors
Kumagai, Hiroo
Yamakami, Kazuo
Takechi, Hanako
Oshima, Naoki
Oda, Takashi
Sakurai, Yutaka
Yamamoto, Kojiro
Yoshizawa, Nobuyuki
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It is well known that glomerulonephritis can occur after streptococcal infection, which is classically referred to as acute poststreptococcal glomerulonephritis (APSGN).
The pathogenic mechanism of APSGN has been described by so-called immune complex theory, which involves glomerular deposition of nephritogenic streptococcal antigen and subsequent formation of immune complexes in situ and/or the deposition of circulating antigen-antibody complexes.
However, the exact entity of the causative antigen has remained a matter of debate.
We isolated a nephritogenic antigen for APSGN from the cytoplasmic fractions of group A streptococcus (GAS) depending on the affinity for IgG of APSGN patients.
The amino acid and the nucleotide sequences of the isolated protein revealed to be highly identical to those of reported plasmin(ogen) receptor of GAS.
Thus, we termed this antigen nephritis-associated plasmin receptor (NAPlr).
Immunofluorescence staining of the renal biopsy tissues with anti-NAPlr antibody revealed glomerular NAPlr deposition in essentially all patients with early-phase APSGN.
Furthermore, glomerular plasmin activity was detected by in situ zymography in the distribution almost identical to NAPlr deposition in renal biopsy tissues of APSGN patients.
These data suggest that NAPlr has a direct, nonimmunologic function as a plasmin receptor and may contribute to the pathogenesis of APSGN by maintaining plasmin activity.
American Psychological Association (APA)
Oda, Takashi& Yoshizawa, Nobuyuki& Yamakami, Kazuo& Sakurai, Yutaka& Takechi, Hanako& Yamamoto, Kojiro…[et al.]. 2012. The Role of Nephritis-Associated Plasmin Receptor (NAPlr) in Glomerulonephritis Associated with Streptococcal Infection. BioMed Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991692
Modern Language Association (MLA)
Oda, Takashi…[et al.]. The Role of Nephritis-Associated Plasmin Receptor (NAPlr) in Glomerulonephritis Associated with Streptococcal Infection. BioMed Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-991692
American Medical Association (AMA)
Oda, Takashi& Yoshizawa, Nobuyuki& Yamakami, Kazuo& Sakurai, Yutaka& Takechi, Hanako& Yamamoto, Kojiro…[et al.]. The Role of Nephritis-Associated Plasmin Receptor (NAPlr) in Glomerulonephritis Associated with Streptococcal Infection. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991692