Molecular Imaging in Tracking Tumor Stem-Like Cells
Joint Authors
Zhang, Hong
Xia, Tian
Tian, Mei
Li, Chenrui
Jiang, Han
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cancer remains a major public health problem in many countries.
It was found to contain a subset of cancer stem cells (CSCs) that are capable of proliferation and self-renewal, and differentiation into various types of cancer cells.
CSCs often display characteristics of chemotherapy resistance and radiotherapy resistance.
Numerous putative biomarkers of CSCs are currently identified including CD133, CD44, CD24, ALDH (aldehyde dehydrogenase), and ABCG2.
Interestingly, no single marker is exclusively expressed by CSCs.
Thus, the various combinations of different biomarkers will be possible to identify CSCs, and considerable work is being done to recognize new ones.
In order to demonstrate the mechanisms of resistance and response to therapy and predict the outcome as well as prognosis, the ways to track and identify CSCs will be extremely important.
The technologies of molecular imaging will reveal mechanisms of cancer progression and provide visual targets for novel therapeutics.
Limited studies were investigated on the detection of various types of CSCs by molecular imaging.
Although the tracking of circulating CSCs is still hampered by technological challenges, personalized diagnosis and therapies of cancers are expected to be established based on increased understanding of molecular imaging of cancer stem-like cells biomarkers.
American Psychological Association (APA)
Xia, Tian& Jiang, Han& Li, Chenrui& Tian, Mei& Zhang, Hong. 2012. Molecular Imaging in Tracking Tumor Stem-Like Cells. BioMed Research International،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-991694
Modern Language Association (MLA)
Xia, Tian…[et al.]. Molecular Imaging in Tracking Tumor Stem-Like Cells. BioMed Research International No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-991694
American Medical Association (AMA)
Xia, Tian& Jiang, Han& Li, Chenrui& Tian, Mei& Zhang, Hong. Molecular Imaging in Tracking Tumor Stem-Like Cells. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-991694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991694