Lysine Acetylation: Elucidating the Components of an Emerging Global Signaling Pathway in Trypanosomes
Joint Authors
Alonso, Victoria Lucia
Serra, Esteban Carlos
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
In the past ten years the number of acetylated proteins reported in literature grew exponentially.
Several authors have proposed that acetylation might be a key component in most eukaryotic signaling pathways, as important as phosphorylation.
The enzymes involved in this process are starting to emerge; acetyltransferases and deacetylases are found inside and outside the nuclear compartment and have different regulatory functions.
In trypanosomatids several of these enzymes have been described and are postulated to be novel antiparasitic targets for the rational design of drugs.
In this paper we overview the most important known acetylated proteins and the advances made in the identification of new acetylated proteins using high-resolution mass spectrometry.
Also, we summarize what is known so far about the acetyltransferases and deacetylases in eukaryotes, focusing on trypanosomes and their potential use as chemotherapeutic targets.
American Psychological Association (APA)
Alonso, Victoria Lucia& Serra, Esteban Carlos. 2012. Lysine Acetylation: Elucidating the Components of an Emerging Global Signaling Pathway in Trypanosomes. BioMed Research International،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-991706
Modern Language Association (MLA)
Alonso, Victoria Lucia& Serra, Esteban Carlos. Lysine Acetylation: Elucidating the Components of an Emerging Global Signaling Pathway in Trypanosomes. BioMed Research International No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-991706
American Medical Association (AMA)
Alonso, Victoria Lucia& Serra, Esteban Carlos. Lysine Acetylation: Elucidating the Components of an Emerging Global Signaling Pathway in Trypanosomes. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-991706
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991706