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New Protein Vector ApE1 for Targeted Delivery of Anticancer Drugs
Joint Authors
Gukasova, N. V.
Bereznikova, A. V.
Severin, E. S.
Pozdniakova, N. V.
Gorokhovets, N. V.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A new chimeric gene ApE1 encoding the receptor-binding domain of the human alpha-fetoprotein fused to a sequence of 22 glutamic acid residues was constructed.
A new bacterial producer strain E.
coli SHExT7 ApE1 was selected for ApE1 production in a soluble state.
A simplified method was developed to purify ApE1 from bacterial biomass.
It was shown that the new vector protein selectively interacts with AFP receptors on the tumor cell surface and can be efficiently accumulated in tumor cells.
In addition, ApE1 was shown to be stable in storage and during its chemical modification.
An increased number of carboxyl groups in the molecule allows the production of cytotoxic compound conjugates with higher drug-loading capacity and enhanced tumor targeting potential.
American Psychological Association (APA)
Pozdniakova, N. V.& Gorokhovets, N. V.& Gukasova, N. V.& Bereznikova, A. V.& Severin, E. S.. 2012. New Protein Vector ApE1 for Targeted Delivery of Anticancer Drugs. BioMed Research International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-991716
Modern Language Association (MLA)
Pozdniakova, N. V.…[et al.]. New Protein Vector ApE1 for Targeted Delivery of Anticancer Drugs. BioMed Research International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-991716
American Medical Association (AMA)
Pozdniakova, N. V.& Gorokhovets, N. V.& Gukasova, N. V.& Bereznikova, A. V.& Severin, E. S.. New Protein Vector ApE1 for Targeted Delivery of Anticancer Drugs. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-991716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991716