Nanoparticulate Adjuvants and Delivery Systems for Allergen Immunotherapy
Joint Authors
Ferrer, Marta
Irache, Juan Manuel
Sanz, María Luisa
Esparza, Irene
De Souza Rebouças, Juliana
Gamazo, Carlos
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In the last decades, significant progress in research and clinics has been made to offer possible innovative therapeutics for the management of allergic diseases.
However, current allergen immunotherapy shows limitations concerning the long-term efficacy and safety due to local side effects and risk of anaphylaxis.
Thus, effective and safe vaccines with reduced dose of allergen have been developed using adjuvants.
Nevertheless, the use of adjuvants still has several disadvantages, which limits its use in human vaccines.
In this context, several novel adjuvants for allergen immunotherapy are currently being investigated and developed.
Currently, nanoparticles-based allergen-delivery systems have received much interest as potential adjuvants for allergen immunotherapy.
It has been demonstrated that the incorporation of allergens into a delivery system plays an important role in the efficacy of allergy vaccines.
Several nanoparticles-based delivery systems have been described, including biodegradable and nondegradable polymeric carriers.
Therefore, this paper provides an overview of the current adjuvants used for allergen immunotherapy.
Furthermore, nanoparticles-based allergen-delivery systems are focused as a novel and promising strategy for allergy vaccines.
American Psychological Association (APA)
De Souza Rebouças, Juliana& Esparza, Irene& Ferrer, Marta& Sanz, María Luisa& Irache, Juan Manuel& Gamazo, Carlos. 2012. Nanoparticulate Adjuvants and Delivery Systems for Allergen Immunotherapy. BioMed Research International،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-991720
Modern Language Association (MLA)
De Souza Rebouças, Juliana…[et al.]. Nanoparticulate Adjuvants and Delivery Systems for Allergen Immunotherapy. BioMed Research International No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-991720
American Medical Association (AMA)
De Souza Rebouças, Juliana& Esparza, Irene& Ferrer, Marta& Sanz, María Luisa& Irache, Juan Manuel& Gamazo, Carlos. Nanoparticulate Adjuvants and Delivery Systems for Allergen Immunotherapy. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-991720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991720