Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination

Joint Authors

Castellino, Francis J.
Bhattacharya, Sarbani
Ploplis, Victoria A.

Source

BioMed Research International

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-19, 19 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-10-14

Country of Publication

Egypt

No. of Pages

19

Main Subjects

Medicine

Abstract EN

In order for invasive pathogens to migrate beyond the site of infection, host physiological barriers such as the extracellular matrix, the basement membrane, and encapsulating fibrin network must be degraded.

To circumvent these impediments, proteolytic enzymes facilitate the dissemination of the microorganism.

Recruitment of host proteases to the bacterial surface represents a particularly effective mechanism for enhancing invasiveness.

Plasmin is a broad spectrum serine protease that degrades fibrin, extracellular matrices, and connective tissue.

A large number of pathogens express plasminogen receptors which immobilize plasmin(ogen) on the bacterial surface.

Surface-bound plasminogen is then activated by plasminogen activators to plasmin through limited proteolysis thus triggering the development of a proteolytic surface on the bacteria and eventually assisting the spread of bacteria.

The host hemostatic system plays an important role in systemic infection.

The interplay between hemostatic processes such as coagulation and fibrinolysis and the inflammatory response constitutes essential components of host defense and bacterial invasion.

The goal of this paper is to highlight mechanisms whereby pathogenic bacteria, by engaging surface receptors, utilize and exploit the host plasminogen and fibrinolytic system for the successful dissemination within the host.

American Psychological Association (APA)

Bhattacharya, Sarbani& Ploplis, Victoria A.& Castellino, Francis J.. 2012. Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination. BioMed Research International،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-991723

Modern Language Association (MLA)

Bhattacharya, Sarbani…[et al.]. Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination. BioMed Research International No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-991723

American Medical Association (AMA)

Bhattacharya, Sarbani& Ploplis, Victoria A.& Castellino, Francis J.. Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-991723

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-991723