Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination
Joint Authors
Castellino, Francis J.
Bhattacharya, Sarbani
Ploplis, Victoria A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-14
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
In order for invasive pathogens to migrate beyond the site of infection, host physiological barriers such as the extracellular matrix, the basement membrane, and encapsulating fibrin network must be degraded.
To circumvent these impediments, proteolytic enzymes facilitate the dissemination of the microorganism.
Recruitment of host proteases to the bacterial surface represents a particularly effective mechanism for enhancing invasiveness.
Plasmin is a broad spectrum serine protease that degrades fibrin, extracellular matrices, and connective tissue.
A large number of pathogens express plasminogen receptors which immobilize plasmin(ogen) on the bacterial surface.
Surface-bound plasminogen is then activated by plasminogen activators to plasmin through limited proteolysis thus triggering the development of a proteolytic surface on the bacteria and eventually assisting the spread of bacteria.
The host hemostatic system plays an important role in systemic infection.
The interplay between hemostatic processes such as coagulation and fibrinolysis and the inflammatory response constitutes essential components of host defense and bacterial invasion.
The goal of this paper is to highlight mechanisms whereby pathogenic bacteria, by engaging surface receptors, utilize and exploit the host plasminogen and fibrinolytic system for the successful dissemination within the host.
American Psychological Association (APA)
Bhattacharya, Sarbani& Ploplis, Victoria A.& Castellino, Francis J.. 2012. Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination. BioMed Research International،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-991723
Modern Language Association (MLA)
Bhattacharya, Sarbani…[et al.]. Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination. BioMed Research International No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-991723
American Medical Association (AMA)
Bhattacharya, Sarbani& Ploplis, Victoria A.& Castellino, Francis J.. Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-991723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991723