Asbestos-Induced Cellular and Molecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis
Joint Authors
Lee, Suni
Kishimoto, Takumi
Hiratsuka, Junichi
Maeda, Megumi
Otsuki, Takemi
Yamamoto, Shoko
Tabata, Rika
Kojima, Yoko
Nishimura, Yasumitsu
Matsuzaki, Hidenori
Hatayama, Tamayo
Hayashi, Hiroaki
Kumagai-Takei, Naoko
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Asbestos causes lung fibrosis known as asbestosis as well as cancers such as malignant mesothelioma and lung cancer.
Asbestos is a mineral silicate containing iron, magnesium, and calcium with a core of SiO2.
The immunological effect of silica, SiO2, involves the dysregulation of autoimmunity because of the complications of autoimmune diseases found in silicosis.
Asbestos can therefore cause alteration of immunocompetent cells to result in a decline of tumor immunity.
Additionally, due to its physical characteristics, asbestos fibers remain in the lung, regional lymph nodes, and the pleural cavity, particularly at the opening sites of lymphatic vessels.
Asbestos can induce chronic inflammation in these areas due to the production of reactive oxygen/nitrogen species.
As a consequence, immunocompetent cells can have their cellular and molecular features altered by chronic and recurrent encounters with asbestos fibers, and there may be modification by the surrounding inflammation, all of which eventually lead to decreased tumor immunity.
In this paper, the brief results of our investigation regarding reduction of tumor immunity of immunocompetent cells exposed to asbestos in vitro are discussed, as are our findings concerned with an investigation of chronic inflammation and analyses of peripheral blood samples derived from patients with pleural plaque and mesothelioma that have been exposed to asbestos.
American Psychological Association (APA)
Matsuzaki, Hidenori& Maeda, Megumi& Lee, Suni& Nishimura, Yasumitsu& Kumagai-Takei, Naoko& Hayashi, Hiroaki…[et al.]. 2012. Asbestos-Induced Cellular and Molecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis. BioMed Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991731
Modern Language Association (MLA)
Matsuzaki, Hidenori…[et al.]. Asbestos-Induced Cellular and Molecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis. BioMed Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-991731
American Medical Association (AMA)
Matsuzaki, Hidenori& Maeda, Megumi& Lee, Suni& Nishimura, Yasumitsu& Kumagai-Takei, Naoko& Hayashi, Hiroaki…[et al.]. Asbestos-Induced Cellular and Molecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-991731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991731