Temporal and Quantitative Analysis of Atherosclerotic Lesions in Diet-Induced Hypercholesterolemic Rabbits
Joint Authors
Fan, Jianglin
Huang, Bingqiao
Yu, Qi
Li, Yafeng
Liu, Enqi
Zhao, Sihai
Yang, Peigang
Waqar, Ahmed Bilal
Wang, Yanli
Chen, Yulong
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The diet-induced atherosclerotic rabbit is an ideal model for atherosclerosis study, but temporal changes in atherosclerotic development in hypercholesterolemic rabbits are poorly understood.
Japanese white rabbits were fed a high-cholesterol diet to induce sustained hypercholesterolemia, and each group of 10–12 animals was then sacrificed at 6, 12, 16, or 28 weeks.
The rabbit aortas were harvested, and the sizes of the gross and intima atherosclerotic lesions were quantified.
The cellular component of macrophages (Mφs) and smooth muscle cells (SMCs) in aortic intimal lesions was also quantified by immunohistochemical staining, and the correlation between plasma cholesterol levels and the progress of atherosclerotic lesions was studied.
The ultrastructure of the atherosclerotic lesions was observed by transmission electron microscopy (TEM).
Widely variable atherosclerotic plaques were found from 6 weeks to 28 weeks, and the lesional progress was closely correlated with cholesterol exposure.
Interestingly, a relatively reduced accumulation of Mφ, an increased numbers of SMCs, and a damaged endothelial layer were presented in advanced lesions.
Moreover, SMCs were closely correlated with cholesterol exposure and lesional progress for the whole period.
Cholesterol exposure directly determines atherosclerotic progress in a rabbit model, and the changes in the cellular component of advanced lesions may affect plaque stability in an atherosclerotic rabbit model.
American Psychological Association (APA)
Yu, Qi& Li, Yafeng& Waqar, Ahmed Bilal& Wang, Yanli& Huang, Bingqiao& Chen, Yulong…[et al.]. 2012. Temporal and Quantitative Analysis of Atherosclerotic Lesions in Diet-Induced Hypercholesterolemic Rabbits. BioMed Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991742
Modern Language Association (MLA)
Yu, Qi…[et al.]. Temporal and Quantitative Analysis of Atherosclerotic Lesions in Diet-Induced Hypercholesterolemic Rabbits. BioMed Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-991742
American Medical Association (AMA)
Yu, Qi& Li, Yafeng& Waqar, Ahmed Bilal& Wang, Yanli& Huang, Bingqiao& Chen, Yulong…[et al.]. Temporal and Quantitative Analysis of Atherosclerotic Lesions in Diet-Induced Hypercholesterolemic Rabbits. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991742