Associations of Polymorphisms in the Apolipoprotein APOA1-C3-A5 Gene Cluster with Acute Coronary Syndrome
Joint Authors
Feng, Jing Bo
Wang, Zhi Xiao
Li, Dong Sheng
Zhu, Ming An
Zhu, Jing
Ding, Yan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Acute coronary syndromes (ACSs) are clinically cardiovascular events associated with dyslipidemia in common.
Single nucleotide polymorphisms (SNPs) and haplotypes in the APOA1/C3/A5 gene cluster are associated with diabetes and familial combined hyperlipidaemia (FCH).
Little is known about whether the polymorphisms in these genes affect lipid homeostasis in patients with ACSs.
The present paper aimed to examine these associations with 4 SNPs in the APOA1 −75G>A, the APOC3 −455T>C, and APOA5 −1131T>C, c.553G>T variant to ACSs in Chinese Han.
Methods.
Chinese Han of 229 patients with ACSs and 254 unrelated controls were analyzed.
Four SNPs in APOA1/C3/A5 cluster were genotyped and lipid was determined.
Results.
Our data show that minor allelic frequencies of APOC3 −455T >C, APOA5 −1131T>C, and c.553G>T polymorphisms in patients with ACSs were significantly higher than control group (P<0.05).
Furthermore, the 3 polymorphic sites were strongly of linkage disequilibrium, and minor alleles of 3 SNP sites had higher TG level than wild alleles (P<0.05), APOC3 −455C and APOA5 c.553T allele carriers also had lower level of HDL-C.
Conclusions.
The minor alleles of APOC3 −455T >C, APOA5 −1131T>C, and c.553G>T polymorphisms are closely associated with ACSs.
American Psychological Association (APA)
Ding, Yan& Zhu, Ming An& Wang, Zhi Xiao& Zhu, Jing& Feng, Jing Bo& Li, Dong Sheng. 2012. Associations of Polymorphisms in the Apolipoprotein APOA1-C3-A5 Gene Cluster with Acute Coronary Syndrome. BioMed Research International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-991745
Modern Language Association (MLA)
Ding, Yan…[et al.]. Associations of Polymorphisms in the Apolipoprotein APOA1-C3-A5 Gene Cluster with Acute Coronary Syndrome. BioMed Research International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-991745
American Medical Association (AMA)
Ding, Yan& Zhu, Ming An& Wang, Zhi Xiao& Zhu, Jing& Feng, Jing Bo& Li, Dong Sheng. Associations of Polymorphisms in the Apolipoprotein APOA1-C3-A5 Gene Cluster with Acute Coronary Syndrome. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-991745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991745