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Diverse Functions of Pulmonary Collectins in Host Defense of the Lung
Joint Authors
Kuroki, Yoshio
Ariki, Shigeru
Nishitani, Chiaki
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Pulmonary surfactant is a mixture of lipids and proteins that covers alveolar surfaces and keeps alveoli from collapsing.
Four specific proteins have been identified in surfactant.
Among them, two C-type lectins, surfactant proteins A and D (SP-A and SP-D), are known to be implicated in host defense and regulation of inflammatory responses of the lung.
These host defense lectins are structurally characterized by N-terminal collagen-like domains and lectin domains and are called pulmonary collectins.
They prevent dissemination of infectious microbes by their biological activities including agglutination and growth inhibition.
They also promote clearance of microbes by enhancing phagocytosis in macrophages.
In addition, they interact with the other pattern-recognition molecules, including Toll-like receptors (TLRs) and TLR-associated molecules, CD14 and MD-2, and regulate inflammatory responses.
Furthermore, recent studies have demonstrated that these collectins modulate functions of neutrophil-derived innate immune molecules by interacting with them.
These findings indicate that pulmonary collectins play critical roles in host defense of the lung.
American Psychological Association (APA)
Ariki, Shigeru& Nishitani, Chiaki& Kuroki, Yoshio. 2012. Diverse Functions of Pulmonary Collectins in Host Defense of the Lung. BioMed Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991757
Modern Language Association (MLA)
Ariki, Shigeru…[et al.]. Diverse Functions of Pulmonary Collectins in Host Defense of the Lung. BioMed Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-991757
American Medical Association (AMA)
Ariki, Shigeru& Nishitani, Chiaki& Kuroki, Yoshio. Diverse Functions of Pulmonary Collectins in Host Defense of the Lung. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991757